🎯 Quick Overview
Trailer
- Director: Gerard Barrett
- Genre: Biography, Drama
- Release year: 2016
- Runtime (length): 1h 28min
- IMDb rating: 6.6/10 (35,955 votes)
- Rotten Tomatoes: 18%
😅 Plot Summary – Badly Explained
A journalist starts seeing things, gets misdiagnosed a lot, and then one doctor finally figures out it’s not all in her head, but actually *in* her head… in a bad way.
🍿 Brain on Fire: Detailed Plot Synopsis
Introduction and Early Symptoms
Susannah Cahalan, a bright and ambitious young journalist at the New York Post, is living a vibrant life. She’s excelling at her job and enjoying a budding romance. However, her life takes a sudden turn when she starts experiencing strange symptoms, including mood swings and memory lapses. Initially, these symptoms are subtle, but they gradually escalate, causing concern among her friends and family. Doctors struggle to diagnose her condition, attributing her problems to stress and overwork.

The Descent into Madness
As Susannah’s condition worsens, she begins experiencing seizures and hallucinations, leading to erratic and unpredictable behavior. She becomes increasingly detached from reality, struggling to recognize loved ones and losing control of her actions. Her behavior becomes alarming, and she’s eventually admitted to a hospital for psychiatric evaluation. Doctors are baffled by her symptoms, initially suspecting mental illness. Susannah undergoes numerous tests, but no clear diagnosis emerges, leaving her family and friends desperate for answers.

The Breakthrough Diagnosis
Despite the initial focus on psychiatric explanations, one doctor, Dr. Souhel Najjar, suspects a neurological cause. He conducts further tests, including a brain biopsy, which reveals a rare autoimmune disease: anti-NMDA receptor encephalitis. This condition causes the immune system to attack the brain, leading to inflammation and a range of neurological and psychiatric symptoms. Dr. Najjar’s accurate diagnosis provides a glimmer of hope for Susannah and her family, offering a path towards treatment and recovery.

⚠️ Spoilers and Ending Explained
🎬 Cast & Characters
- Susannah Cahalan (Chloë Grace Moretz): A young journalist whose life is derailed by a rare and mysterious autoimmune disease affecting her brain.
- Stephen Grywalski (Thomas Mann): Susannah’s supportive boyfriend who struggles to understand and cope with her sudden illness.
- Tom Cahalan (Richard Armitage): Susannah’s father, who fiercely advocates for her and seeks answers when her health deteriorates.
- Rhona Nack (Carrie-Anne Moss): Susannah’s mother, who provides emotional support as Susannah battles a mysterious illness.
- Dr. Souhel Najjar (Navid Negahban): The determined doctor who finally diagnoses Susannah’s rare autoimmune disease and leads her treatment.
💬 Memorable Quotes
- Susannah Cahalan: “Have you ever been trapped? Lost in your own body, lost in your own mind, lost in time? So desperate to escape, to just… Get out.” – Opening line, setting the stage for her terrifying experience.
- Dr. Najjar: “There’s something else going on here. Something we’re missing.” – Highlights his persistence in finding the true cause of Susannah’s illness when others dismissed it as psychiatric.
💰Box Office
- Budget: $15,000,000
- Domestic Gross: $0
- Worldwide Gross: $10,846
💥 Brain on Fire Reviews
Personal Review
I was really drawn in by Chloe Grace Moretz’s performance; she really sells the confusion and fear. The scene where she can’t see her reflection in the mirror? Chilling! It’s a tough movie to watch because it deals with such a scary illness, but it also gives hope that even when things seem impossible, answers can be found. I definitely felt empathy for Susannah and her family’s struggle.
- Who would enjoy:
- “Viewers interested in medical mysteries”
- “Fans of biographical dramas”
- “Individuals interested in autoimmune diseases”
- “Those who appreciate strong performances by lead actresses”
- Content warnings ⚠:
- “Seizures”
- “Hallucinations”
- “Psychiatric distress”
- “Medical procedures”
- “Brief nudity”
Professional Reviews
- IndieWire: “While Moretz delivers a committed performance, ‘Brain on Fire’ suffers from a lack of depth, reducing a complex medical journey into a simplistic narrative. The film struggles to balance the medical mystery with the human drama, resulting in a tonally uneven experience.
- The Hollywood Reporter: “The film offers a sanitized version of Cahalan’s ordeal, lacking the gritty realism needed to truly convey the terror of her experience. Despite strong performances, the narrative feels rushed, and the emotional impact is blunted by a formulaic approach.
- Variety: “While ‘Brain on Fire’ tackles an important subject, it does so with a heavy hand, sacrificing nuance for melodrama. Moretz shines, but the film ultimately fails to fully explore the complexities of autoimmune encephalitis and its impact on Cahalan’s life.
Audience Reactions
Chloe Grace Moretz’s acting was spot on, she nailed the role perfectly!: Most viewers found Moretz’s performance to be the highlight, praising her portrayal of the illness’s progression.
The movie increased awareness of autoimmune encephalitis and the importance of perserverance in diagnosis: Viewers appreciated the film’s depiction of a rare disease and the challenges faced in getting a diagnosis, with several viewers attesting to the accuracy of the portrayal.
Overall Consensus: Despite some mixed reviews from critics, ‘Brain on Fire’ resonates with audiences for its emotional impact, Chloe Grace Moretz’s performance, and its awareness of autoimmune encephalitis, making it a worthwhile watch for those interested in medical dramas.
Awards
🛠️ Behind the Scenes
- “Brain on Fire is based on Susannah Cahalan’s memoir ‘Brain on Fire: My Month of Madness’, detailing her struggle with a rare autoimmune disease.”
- “The film highlights the challenges of diagnosing rare neurological conditions and the importance of persistent medical investigation.”
- “The movie aims to raise awareness about autoimmune encephalitis and the potential misdiagnosis of neurological disorders as psychiatric illnesses.”
🖥️ How to Watch Brain on Fire?
Brain on Fire is currently available for streaming on various platforms. You can find it on services like Netflix. For rental or purchase, check out options on platforms like Apple TV, Google Play Movies, and Amazon Prime Video. Availability may vary by region.

🎥 Similar Movies
If you enjoyed Brain on Fire, you might like these similar films:
- The Diving Bell and the Butterfly (2007): Portrays the experience of being trapped inside one’s own body due to a rare neurological condition, similar to Susannah’s ordeal.
- Still Alice (2014): Deals with a character’s rapid cognitive decline due to a neurological disease and the impact on their relationships.
- Awakenings (1990): Features a doctor using unconventional methods to treat patients with a rare neurological disorder, reminiscent of Dr. Najjar’s dedication.
- My Beautiful Broken Brain (2014): This documentary follows a woman’s recovery after a stroke leaves her with cognitive difficulties, offering insight into neurological recovery.
🛒 Brain on Fire Related Products
- Brain on Fire: My Month of Madness: The gripping memoir by Susannah Cahalan that inspired the movie, offering a deeper dive into her experience with autoimmune encephalitis.
- Autoimmune Encephalitis Awareness Bracelet: A silicone bracelet to support the AE community, increase public awareness and promote research
🎧 Soundtrack
Brain on Fire features a captivating soundtrack that enhances the movie’s atmosphere and emotional impact. Here are some notable tracks:
You can find the complete soundtrack on Amazon Music and Apple Music.
🤨 FAQ
Yes, ‘Brain on Fire’ is based on the true story of Susannah Cahalan, a journalist who suffered from a rare autoimmune disease called anti-NMDA receptor encephalitis.
Anti-NMDA receptor encephalitis is a rare autoimmune disease where the body’s immune system attacks the NMDA receptors in the brain. This can lead to a range of psychiatric and neurological symptoms.
Brain on Fire was filmed in Vancouver, British Columbia, Canada.
🔥 Bonus Content
Brain On Fire (2016) Ending Explained In Hindi | Based on a true story | Movie Explanations In Hindi
Confused about the ending of Brain on Fire? This video breaks it down in Hindi, making it super easy to understand. Honestly, it cleared up a lot for me and made me appreciate the film even more!
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